Botox is the most heavily used and researched cosmetic product of its kind. It has over a 16 year track record and approval for use in 98 countries. In fact, the safety and efficacy of Botox has been featured in 528 peer reviewed articles in scientific and medical journals. In summary, Botox has been used for years and has been proven to be safe and effective. Your only regret will be not trying it sooner.